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Randomized Controlled Trial
. 2008 Oct;45(8):681-7.
doi: 10.1080/02770900802168695.

Deterioration in asthma control when subjects receiving fluticasone propionate/salmeterol 100/50 mcg Diskus are "stepped-down"

Steven M Koenig  1 , Nancy Ostrom, David Pearlman, Kelli Waitkus-Edwards, Steven Yancey, Barbara A Prillaman, Paul Dorinsky
Affiliations
Randomized Controlled Trial

Deterioration in asthma control when subjects receiving fluticasone propionate/salmeterol 100/50 mcg Diskus are "stepped-down"

Steven M Koenig et al. J Asthma. 2008 Oct.

Abstract

In this study, 647 subjects stable on fluticasone propionate/salmeterol Diskus 100/50 mcg BID (FSC) were randomized to continue FSC 100/50 mcg BID or "step down" to either fluticasone propionate (FP) 100 mcg BID, salmeterol (SAL) 50 mcg BID, or montelukast (MON) 10 mg once daily for 16 weeks. Overall asthma control significantly improved in the FSC group; whereas, "stepping down" to FP, SAL, or MON resulted in deterioration in asthma control, as determined by decreased measures of lung function and clinical features. This study provides support that treatment of both inflammation and smooth muscle dysfunction may be necessary to achieve and maintain asthma control in patients uncontrolled on ICS.

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