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Review
. 2008 Nov;9(11):1157-62.

Multiple indications for anti-inflammatory apolipoprotein mimetic peptides

Brian J Van Lenten  1 , Mohamad Navab, G M Anantharamaiah, Georgette M Buga, Srinivasa T Reddy, Alan M Fogelman
Affiliations
Review

Multiple indications for anti-inflammatory apolipoprotein mimetic peptides

Brian J Van Lenten et al. Curr Opin Investig Drugs. 2008 Nov.

Abstract

Apolipoprotein mimetic peptides dramatically reduce atherosclerosis in animal models, and may be an excellent mode of therapy to treat a variety of vascular inflammatory conditions, including atherosclerosis. Studies of apolipoprotein mimetic peptides in models of inflammatory disorders other than atherosclerosis, including viral influenza, asthma, chronic rejection after heart transplantation, sickle cell disease, scleroderma, diabetes, cognitive dysfunction and renal inflammation, suggest that apolipoprotein mimetic peptides may have efficacy in a wide range of inflammatory conditions.

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References

    1. Owens BJ, Anantharamaiah GM, Kahlon JB, Srinivas RV, Compans RW, Segrest JP. Apolipoprotein A-I and its amphipathic helix peptide analogues inhibit human immunodeficiency virus-induced syncytium formation. J Clin Invest. 1990;86(4):1142–1150. • This report is one of the earliest to recognize the therapeutic potential of mimetic peptides

    1. Badimon JJ, Badimon L, Fuster V. Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J Clin Invest. 1990;85(4):1234–1241. • A seminal paper that reported that infusion of HDL into rabbits reduced arterial atherosclerotic lesions

    1. Plump AS, Scott CJ, Breslow JL. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A. 1994;91(20):9607–9611. • A highly important report demonstrating that increasing the availability of apoA-I increases HDL levels and reduces atheroslcerotic lesions in apoE-deficient mice

    1. Mendez AJ, Anantharamaiah GM, Segrest JP, Oram JF. Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol. J Clin Invest. 1994;94(4):1698–1705. - PMC - PubMed

    1. Anantharamaiah GM, Jones JL, Brouillette CG, Schmidt CF, Chung BH, Hughes TA, Bhown AS, Segrest JP. Studies of synthetic peptide analogs of the amphipathic helix. Structure of complexes with dimyristoyl phosphatidylcholine. J Biol Chem. 1985;260(18):10248–10255. • This is one of the earliest reports on apoA-I mimetic peptides

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