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. 1991 Jul;238(4):200-2.
doi: 10.1007/BF00314780.

Parvalbumin-immunoreactive neurons in the cortex in Pick's disease

H Arai  1 , I Noguchi, Y Makino, K Kosaka, C W Heizmann, R Iizuka
Affiliations

Parvalbumin-immunoreactive neurons in the cortex in Pick's disease

H Arai et al. J Neurol. 1991 Jul.

Abstract

Parvalbumin (a calcium-binding protein)-immunoreactive (PV-Ir) neurons in the cerebral cortex were examined in 20 postmortem brains obtained from elderly controls and patients with Pick's disease (PD). The type of PV-Ir neurons and their distribution in control and PD brains were similar. The number of PV-Ir neurons in PD brains did not differ significantly from that in the control brains either. These findings suggested that PV-Ir neurons in the cortex are not affected in PD brains. A significant loss of PV-Ir neurons has already been reported in brains obtained from patients with Alzheimer-type dementia (ATD), and the present results suggest the possibility that the damage of PV-Ir neurons might be comparatively selective for ATD brains.

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