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. 2008 Dec 1;18(23):6050-3.
doi: 10.1016/j.bmcl.2008.10.032. Epub 2008 Oct 11.

Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246

Yoshihito Shiono  1 , Keiko Shimanuki, Fuminori Hiramatsu, Takuya Koseki, Murayama Tetsuya, Nozomi Fujisawa, Ken-ichi Kimura
Affiliations

Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246

Yoshihito Shiono et al. Bioorg Med Chem Lett. .

Abstract

Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher's method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.

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