Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Apr;50 Suppl(Suppl):S311-6.
doi: 10.1194/jlr.R800049-JLR200. Epub 2008 Oct 23.

Membrane phospholipid synthesis and endoplasmic reticulum function

Paolo Fagone  1 , Suzanne Jackowski
Affiliations
Review

Membrane phospholipid synthesis and endoplasmic reticulum function

Paolo Fagone et al. J Lipid Res. 2009 Apr.

Abstract

This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships between alterations in lipid composition, regulation of membrane lipid biogenesis, and cellular secretory function are discussed.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Compartmentalization of phospholipid biosynthetic activities. The abbreviations are listed in Table 1.
See this image and copyright information in PMC

References

    1. Fagone P., R. Sriburi, C. Ward-Chapman, M. Frank, J. Wang, C. Gunter, J. W. Brewer, and S. Jackowski. 2007. Phospholipid biosynthesis program underlying membrane expansion during B lymphocyte differentiation. J. Biol. Chem. 282 7591–7605. - PubMed
    1. Tian Y., C. Pate, A. Andreolotti, L. Wang, E. Tuomanen, K. Boyd, E. Claro, and S. Jackowski. 2008. Cytokine secretion requires phosphatidylcholine synthesis. J. Cell Biol. 181 945–957. - PMC - PubMed
    1. Matsuura S., R. Masuda, O. Sakai, and Y. Tashiro. 1983. Immunoelectron microscopy of the outer membrane of rat hepatocyte nuclear envelopes in relation to the rough endoplasmic reticulum. Cell Struct. Funct. 8 1–9. - PubMed
    1. Lavoie C., and J. Paiement. 2008. Topology of molecular machines of the endoplasmic reticulum: a compilation of proteomics and cytological data. Histochem. Cell Biol. 129 117–128. - PMC - PubMed
    1. Shindou H., and T. Shimizu. 2008. Acyl-CoA: lysophospholipid acyltransferases. J. Biol. Chem. 284 1–5. - PubMed

Publication types

MeSH terms

LinkOut - more resources