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Review
. 2008 Dec;47(12):1561-2, 1564-7.
doi: 10.1007/s00120-008-1804-4.

[Genetics of male infertility]

[Article in German]
F Tüttelmann  1 , J Gromoll, S Kliesch
Affiliations
Review

[Genetics of male infertility]

[Article in German]
F Tüttelmann et al. Urologe A. 2008 Dec.

Abstract

Genetic causes of male infertility increase in frequency with decreasing sperm concentration (oligo-/azoospermia). The decision about genetic tests should be made after a complete andrological work-up. Common causes comprise chromosomal aberrations (including Klinefelter syndrome), microdeletions of the AZF loci of the Y chromosome, mutations in the gene responsible for cystic fibrosis (CFTR) causing CBAVD and in genes involved in hypogonadotropic hypogonadism (including Kallmann syndrome). Every genetic investigation should be accompanied by comprehensive genetic counselling to help with the interpretation of results and support the patient/the couple concerning consequences for their family planning and treatment options.

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References

    1. Eur J Endocrinol. 1994 Oct;131(4):347-54 - PubMed
    1. J Clin Endocrinol Metab. 2007 Mar;92(3):762-70 - PubMed
    1. Eur J Endocrinol. 1998 Sep;139(3):298-303 - PubMed
    1. Pituitary. 2007;10(4):381-91 - PubMed
    1. Reprod Biomed Online. 2007 Dec;15(6):643-58 - PubMed

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