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. 2010 Sep;7(3):317-22.
doi: 10.1093/ecam/nen001. Epub 2008 Feb 4.

Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats

Vishnu Kumar  1 , Mohammad Mubin Khan, Ashok Kumar Khanna, Ranjana Singh, Sushma Singh, Ramesh Chander, Farzana Mahdi, Abbas Ali Mahdi, Jitendra Kumar Saxena, Raj Kumar Singh
Affiliations

Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats

Vishnu Kumar et al. Evid Based Complement Alternat Med. 2010 Sep.

Abstract

The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg(-1) b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50-500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.

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Figures

Figure 1.
Figure 1.
Values are mean ± SD of six rats aP < 0.001, bP < 0.01. Hyperlipidemic (control Group 2) was compared with control (Group 1). Hyperlipidemic + A. indicus treated (Group 3) and hyperlipidemic + gemfibrozil (Group 4) was compared with hyperlipidemic control (Group 2).
Figure 2.
Figure 2.
Values are mean ± SD of six rats aP < 0.001, bP < 0.01. Hyperlipidemic (control Group 2) was compared with control (Group 1). Hyperlipidemic + A. indicus treated (Group 3) and hyperlipidemic + gemfibrozil (Group 4) was compared with hyperlipidemic control (Group 2).
Figure 3.
Figure 3.
Values are mean ± SD of six rats aP < 0.001, bP < 0.01. Hyperlipidemic control (Group 2) was compared with control (Group 1). Hyperlipidemic + A. indicus treated (Group 3) and hyperlipidemic + gemfibrozil (Group 4) was compared with hyperlipidemic control (Group 2).
Figure 4.
Figure 4.
Values are mean ± SD of four separate observations. aP < 0.001, bP < 0.001, cP < 0.05, NS = non significant. The systems added with A. indicus were compared with those without adding A. indicus.
Figure 5.
Figure 5.
Values are mean ± SD of four separate observations. aP < 0.001, bP < 0.001, cP < 0.05, NS = non significant. The systems added with A. indicus were compared with those without adding A. indicus.
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