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. 2008 Aug;9(3):144-8.
doi: 10.1111/j.1751-2980.2008.00336.x.

Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease

Mohammed A Alzoghaibi  1 , Ibramim A Al-Mofleh, Abdulrhman M Al-Jebreen
Affiliations

Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease

Mohammed A Alzoghaibi et al. J Dig Dis. 2008 Aug.

Abstract

Objective: To measure the serum levels of neutrophils chemokine granulocyte chemotactic protein-2 (GCP-2) and interleukin-8 (IL-8) in Crohn's disease (CD) and ulcerative colitis (UC) patients and compare them with serum levels of growth-related oncogene (GRO-alpha).

Methods: Forty-two patients with inflammatory bowel disease (24 CD and 18 UC) and 38 matched healthy subjects were recruited. Their serum GCP-2, IL-8 and GRO-alpha were measured by a specific enzyme immunoassay kit.

Results: The serum levels of GCP-2 were significantly higher in the CD than the UC patients but lower than in the healthy subjects. The GCP-2 in the UC patients were significantly lower than in the healthy subjects. The GRO-alpha levels were significantly higher in the IBD patients than in the healthy subjects. The IL-8 levels were under the detectable limit in both the IBD and the healthy subjects.

Conclusion: In this group of patients, GCP-2 did not participate in the inflammatory response in IBD. GRO-alpha could be an important factor that enhances the inflammatory state in IBD.

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