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Comment
. 2008 Oct 17;135(2):209-11.
doi: 10.1016/j.cell.2008.09.049.

A ubiquitin-like protein unleashes ubiquitin ligases

Nabiha Huq Saifee  1 , Ning Zheng
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A ubiquitin-like protein unleashes ubiquitin ligases

Nabiha Huq Saifee et al. Cell. .
Free article

Abstract

Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ubiquitin or ubiquitin-like proteins.

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