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Comment
. 2008 Oct 23;60(2):192-4.
doi: 10.1016/j.neuron.2008.10.003.

A role for retinoic acid in homeostatic plasticity

Rachel D Groth  1 , Richard W Tsien
Affiliations
Comment

A role for retinoic acid in homeostatic plasticity

Rachel D Groth et al. Neuron. .

Abstract

Prolonged changes in neuronal activity trigger compensatory modifications in synaptic function to restore firing rates to normal levels. In this issue of Neuron, Aoto et al. demonstrate that synthesis of retinoic acid offsets chronic network inactivity by increasing synaptic strength through upregulation of GluR1 receptors.

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