MITAgating viral infection
- PMID: 18957261
- DOI: 10.1016/j.immuni.2008.09.010
MITAgating viral infection
Abstract
Two recent papers, one in this issue of Immunity (Zhong et al., 2008), report the identification of a membrane protein, termed MITA or STING, that activates the transcription factor IRF3 to induce type-I interferons to mitigate viral infection.
Comment on
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Innate recognition of viruses.Immunity. 2007 Sep;27(3):370-83. doi: 10.1016/j.immuni.2007.08.012. Immunity. 2007. PMID: 17892846 Review.
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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.Immunity. 2008 Oct 17;29(4):538-50. doi: 10.1016/j.immuni.2008.09.003. Epub 2008 Sep 25. Immunity. 2008. PMID: 18818105
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