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. 2009 Jan;94(1):74-80.
doi: 10.1210/jc.2008-0708. Epub 2008 Oct 28.

Fertility preservation in girls with turner syndrome: prognostic signs of the presence of ovarian follicles

Birgit Borgström  1 , Julius Hreinsson, Carsten Rasmussen, Maryam Sheikhi, Gabriel Fried, Victoria Keros, Margareta Fridström, Outi Hovatta
Affiliations

Fertility preservation in girls with turner syndrome: prognostic signs of the presence of ovarian follicles

Birgit Borgström et al. J Clin Endocrinol Metab. 2009 Jan.

Erratum in

  • J Clin Endocrinol Metab. 2009 Apr;94(4):1478. Birgit, Borgström [corrected to Borgström, Birgit]; Julius, Hreinsson [corrected to Hreinsson, Julius]; Carsten, Rasmussen [corrected to Rasmussen, Carsten]; Maryam, Sheikhi [corrected to Sheikhi, Maryam]; Gabriel, Fried [corrected to Fried, Gabriel]; Vi

Abstract

Context: Many girls with Turner syndrome have follicles in their ovaries at adolescence.

Objective: Our objective was to study which girls might benefit from ovarian tissue freezing for fertility preservation.

Design: Clinical and laboratory parameters and ovarian follicle counts were analyzed among girls referred by 25 pediatric endocrinologists.

Subjects and setting: Fifty-seven girls with Turner syndrome, aged 8-19.8 yr, were studied at a university hospital.

Interventions: Ovarian tissue was biopsied laparoscopically, studied for the presence of follicles, and cryopreserved. Blood samples were drawn for hormone measurements.

Main outcome measures: Presence of follicles in the biopsied tissue related to age, signs of spontaneous puberty, karyotype, and serum concentrations of gonadotropins and anti-Müllerian hormone were assessed.

Results: Ovarian biopsy was feasible in 47 of the 57 girls. In 15 of the 57 girls (26%), there were follicles in the tissue piece analyzed histologically. Six of seven girls (86%) with mosaicism, six of 22 (27%) with structural chromosomal abnormalities, and three of 28 with karyotype 45X (10.7%) had follicles. Eight of the 13 girls (62%) with spontaneous menarche had follicles, and 11 of the 19 girls (58%) who had signs of spontaneous puberty had follicles. The age group 12-16 yr had the highest proportion of girls with follicles. Normal FSH and anti-Müllerian hormone concentrations for age and pubertal stage were more frequent in girls with follicles.

Conclusions: Signs of spontaneous puberty, mosaicism, and normal hormone concentrations were positive and statistically significant but not exclusive prognostic factors as regards finding follicles.

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