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. 2009 Feb;32(2):329-34.
doi: 10.2337/dc08-1625. Epub 2008 Oct 28.

Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts

Brian H Chen  1 , Yiqing Song, Eric L Ding, Christian K Roberts, JoAnn E Manson, Nader Rifai, Julie E Buring, J Michael Gaziano, Simin Liu
Affiliations

Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts

Brian H Chen et al. Diabetes Care. 2009 Feb.

Abstract

Objective: The purpose of this study was to investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women.

Research design and methods: We conducted two prospective case-control studies nested in the Women's Health Study (WHS) and Physicians' Health Study II (PHS II). In the WHS, during a median of 10-years of follow-up, 359 postmenopausal women, who were apparently healthy at baseline and later developed type 2 diabetes, were prospectively matched with 359 healthy control subjects. In the PHS II, with 8 years of total follow-up, 170 men, who were apparently healthy at baseline and later developed type 2 diabetes, were matched with 170 healthy control subjects. Control subjects were matched by age, race, and time of blood draw.

Results: Resistin levels at baseline were significantly higher in women than in men (P = 0.003) and in case patients than in control subjects for both women (P < 0.001) and men (P = 0.07). After adjustment for matching factors, physical activity, alcohol intake, smoking, and family history of diabetes, the relative risk of type 2 diabetes comparing the highest to the lowest quartile of resistin in women was 2.22 ([95% CI 1.32-3.73]; Ptrend = 0.002). This association was attenuated after further adjustment for BMI (1.51 [0.86-2.65]; Ptrend = 0.20) or C-reactive protein (1.18 [0.68-2.07]; Ptrend = 0.60). A similar but weaker pattern was observed in men.

Conclusions: Elevated levels of circulating resistin were significantly related to increased risk of type 2 diabetes, which appears to be partially accounted for by adiposity and the inflammatory process.

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