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Randomized Controlled Trial
. 2009 Feb;32(2):215-20.
doi: 10.2337/dc08-0687. Epub 2008 Oct 28.

One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes

Bonnie J Brehm  1 , Barbara L Lattin, Suzanne S Summer, Jane A Boback, Gina M Gilchrist, Ronald J Jandacek, David A D'Alessio
Affiliations
Randomized Controlled Trial

One-year comparison of a high-monounsaturated fat diet with a high-carbohydrate diet in type 2 diabetes

Bonnie J Brehm et al. Diabetes Care. 2009 Feb.

Abstract

Objective: The purpose of this study was to compare the effects of high-monounsaturated fatty acid (MUFA) and high-carbohydrate (CHO) diets on body weight and glycemic control in men and women with type 2 diabetes.

Research design and methods: Overweight/obese participants with type 2 diabetes (n = 124, age = 56.5 +/- 0.8 years, BMI = 35.9 +/- 0.3 kg/m2, and A1C = 7.3 +/- 0.1%) were randomly assigned to 1 year of a high-MUFA or high-CHO diet. Anthropometric and metabolic parameters were assessed at baseline and after 4, 8, and 12 months of dieting.

Results: Baseline characteristics were similar between the treatment groups. The overall retention rate for 1 year was 77% (69% for the high-MUFA group and 84% for the high-CHO group; P = 0.06). Based on food records, both groups had similar energy intake but a significant difference in MUFA intake. Both groups had similar weight loss over 1 year (-4.0 +/- 0.8 vs. -3.8 +/- 0.6 kg) and comparable improvement in body fat, waist circumference, diastolic blood pressure, HDL cholesterol, A1C, and fasting glucose and insulin. There were no differences in these parameters between the groups. A follow-up assessment of a subset of participants (n = 36) was conducted 18 months after completion of the 52-week diet. These participants maintained their weight loss and A1C during the follow-up period.

Conclusions: In individuals with type 2 diabetes, high-MUFA diets are an alternative to conventional lower-fat, high-CHO diets with comparable beneficial effects on body weight, body composition, cardiovascular risk factors, and glycemic control.

Trial registration: ClinicalTrials.gov NCT00622960.

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