doi: 10.1073/pnas.88.18.8062.
Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse
Affiliations
- PMID: 1896452
- PMCID: PMC52446
- DOI: 10.1073/pnas.88.18.8062
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Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse
Proc Natl Acad Sci U S A.
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Abstract
Molecular characterization of a radiation-induced agouti (a)-locus mutation has resulted in the isolation of a segment of DNA that maps at or near the a locus on chromosome 2 in the mouse. This region of DNA is deleted in several radiation- or chemical-induced homozygous-lethal a-locus mutations and is associated with specific DNA structural alterations in two viable a-locus mutations. We propose that DNA probes from this region of chromosome 2 will be useful for ultimately characterizing the individual gene or genes associated with a-locus function.
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