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Case Reports
. 2009 Jan;47(1):208-11.
doi: 10.1128/JCM.01161-08. Epub 2008 Oct 29.

Ciprofloxacin-resistant Salmonella enterica serovar typhi from Kuwait with novel mutations in gyrA and parC genes

Tzonyo Dimitrov  1 , Ali A Dashti, Ossama Albaksami, Edet E Udo, Mehrez M Jadaon, M John Albert
Affiliations
Case Reports

Ciprofloxacin-resistant Salmonella enterica serovar typhi from Kuwait with novel mutations in gyrA and parC genes

Tzonyo Dimitrov et al. J Clin Microbiol. 2009 Jan.

Abstract

Blood isolates of Salmonella enterica serovar Typhi from two recently returned Bangladeshi patients in Kuwait were ciprofloxacin resistant, with ciprofloxacin MICs of 12 mg/liter for both isolates. Both isolates had three novel gyrA mutations (55-Leu-->Trp, 87-Asp-->Ala, and 106-Gln-->Arg) and three novel parC mutations (84-Glu-->Lys, 106-Trp-->Gly, and 128-Tyr-->Asp).

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Figures

FIG. 1.
FIG. 1.
QRDR of the gyrA gene of serovar Typhi, with base changes reported previously and now. The QRDR spans nucleotides 161 to 514. The triplet bases with changes are underlined with the amino acids indicated above them. The underlined triplet bases in lowercase letters have been reported previously. The underlined triplet bases in capital letters have been found in the present study.
FIG. 2.
FIG. 2.
QRDR of the parC gene of serovar Typhi, with base changes reported previously and now. The QRDR spans nucleotides 34 to 390. The triplet bases with changes are underlined with the amino acids indicated above them. The underlined triplet bases in lowercase letters have been reported previously. The underlined triplet bases in capital letters have been found in the present study.
See this image and copyright information in PMC

References

    1. Ahmed, D., L. T. D'Costa, K. Alam, G. B. Nair, and M. A. Hossain. 2006. Multi-resistant Salmonella enterica serovar Typhi isolates with high-level resistance to ciprofloxacin in Dhaka, Bangladesh. Antimicrob. Agents Chemother. 503516-3517. - PMC - PubMed
    1. Bhan, M. K., R. Bhal, and S. Bhatnagar. 2005. Typhoid and paratyphoid fever. Lancet 366749-762. - PubMed
    1. Brown, J. C., P. M. A. Shanahan, M. V. Jesudason, C. J. Thomson, and S. G. B. Amyes. 1996. Mutations responsible for reduced susceptibility to 4-quinolones in clinical isolates of multi-resistant Salmonella typhi in India. J. Antimicrob. Chemother. 37891-900. - PubMed
    1. Centers for Disease Control and Prevention. 2000. Standardized molecular subtyping of food-borne bacterial pathogen by pulsed-field gel electrophoresis: training manual. Centers for Disease Control and Prevention, Atlanta, GA.
    1. Chau, T. T., J. I. Campbell, C. M. Galindo, N. V. M. Hoang, T. S. Diep, T. T. T. Nga, N. V. V. Chau, P. Q. Tuan, A. L. Page, R. L. Ochiai, C. Schultsz, J. Wain, Z. A. Bhutta, C. M. Parry, S. K. Bhattacharya, S. Dutta, M. Agtini, B. Dong, Y. Honghui, D. D. Anh, D. G. Canh, A. Naheed, M. J. Albert, R. Phetsouvanh, P. N. Newton, B. Basnyat, A. Arjyal, T. T. P. La, N. N. Rang, L. T. Phuong, P. V. B. Bay, L. von Seidlein, G. Dougan, J. D. Clemens, H. Vinh, T. T. Hien, N. T. Chinh, C. J. Costa, J. Farrar, and C. Dolecek. 2007. Antimicrobial drug resistance of Salmonella enterica serovar Typhi in Asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob. Agents Chemother. 514315-4323. - PMC - PubMed

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