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Review
. 2009 Jan;23(1):3-9.
doi: 10.1038/leu.2008.291. Epub 2008 Oct 30.

Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma

R A Kyle  1 , S V Rajkumar
Affiliations
Review

Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma

R A Kyle et al. Leukemia. 2009 Jan.

Erratum in

  • Leukemia. 2014 Apr;28(4):980

Abstract

New systems have emerged for diagnosis, staging and response assessment in multiple myeloma (MM). The diagnostic and response criteria recommended are primarily derived from the International Myeloma Working Group, with certain updates and clarifications. The International Staging System is the current standard for staging of myeloma. A new risk stratification model is provided to specifically define high-risk patients who may benefit from novel therapeutic strategies. This paper provides the current criteria for diagnosis, staging, risk stratification and response assessment of MM.

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References

    1. Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clinic Proc. 2003;78:21–33. - PubMed
    1. Snozek CLH, Katzmann JA, Kyle RA, Dispenzieri A, Larson D, Therneau TM, et al. Prognostic value of the serum free light chain ratio in newly diagnosed myeloma: proposed incorporation into the International Staging System. Leukemia. 2008;22:1933–1937. - PMC - PubMed
    1. Rajkumar SV, Kyle RA, Therneau TM, Melton LJ, III, Bradwell AR, Clark RJ, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance (MGUS) Blood. 2005;106:812–817. - PMC - PubMed
    1. Dispenzieri A, Kyle RA, Katzmann JA, Therneau TM, Larson D, Benson J, et al. Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma. Blood. 2008;111:785–789. - PMC - PubMed
    1. Dingli D, Kyle RA, Rajkumar SV, Nowakowski GS, Larson DR, Bida JP, et al. Immunoglobulin free light chains and solitary plasmacytoma of bone. Blood. 2006;108:1979–1983. - PMC - PubMed

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