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Review
. 2008 Oct;5(10):2140-2155.
doi: 10.1002/cbdv.200890195.

KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients

Christian G Hartinger  1   2 , Michael A Jakupec  1 , Stefanie Zorbas-Seifried  1   3 , Michael Groessl  1 , Alexander Egger  1 , Walter Berger  4 , Haralabos Zorbas  3 , Paul J Dyson  2 , Bernhard K Keppler  1
Affiliations
Review

KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients

Christian G Hartinger et al. Chem Biodivers. 2008 Oct.

Abstract

The promising drug candidate indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) is the second Ru-based anticancer agent to enter clinical trials. In this review, which is an update of a paper from 2006 (Hartinger et al., J. Inorg. Biochem. 2006, 100, 891-904), the experimental evidence for the proposed mode of action of this coordination compound is discussed, including transport into the cell via the transferrin cycle and activation by reduction. The results of the early clinical development of KP1019 are summarized in which five out of six evaluated patients experienced disease stabilization with no severe side effects.

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References

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