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. 2008 Oct;13(4):364-70.
doi: 10.1111/j.1542-474X.2008.00247.x.

Correlation of modification of heart rate recovery with adaptation to myocardial ischemia in a model of sequential exercise testings

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Correlation of modification of heart rate recovery with adaptation to myocardial ischemia in a model of sequential exercise testings

Andreas P Michaelides et al. Ann Noninvasive Electrocardiol. 2008 Oct.

Abstract

Background: Heart rate recovery (HRR) has been identified as a reliable predictor of cardiac mortality, correlated with autonomic tone. In a model of sequential exercise testings, we investigated the reproducibility of HRR and the association between HRR modification and myocardial adaptation to ischemia.

Methods: We studied 128 patients (mean age 62 +/- 9 years, 83% males) with angiographically documented coronary artery disease (CAD) and a first positive exercise testing, who agreed to undergo a second exercise testing after 24 hours.

Results: HRR was increased from 25 +/- 10 beats/min at the first exercise testing to 30 +/- 13 beats/min at the second exercise testing (P < 0.001). Thereafter, participants were divided into two groups: Group I comprised 88 patients who presented augmentation of the HRR in the first compared to the second exercise testing, while group II comprised 40 patients who presented unchanged or reduced HRR. The rate-pressure product (RPP) at 1 mm ST-segment depression (ischemic threshold) at the second compared to the first exercise testing were significantly improved in group I patients (2345 +/- 3429 mmHg/min), while it was worsened in group II patients (-630 +/- 2510 mmHg/min) (P < 0.001).

Conclusions: In a model of sequential exercise testings, myocardial adaptation to exercise-induced ischemia was associated with favorable modification of HRR.

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Figures

Figure 1
Figure 1
Number of patients with reduced heart rate recovery (HRR) in relation to the HRR changes. ET = exercise testing.

References

    1. Cole CR, Blackstone EH, Pashkow FJ, et al Heart‐rate recovery immediately after exercise as a predictor of mortality. N Engl J Med 1999;341:1351–1357. - PubMed
    1. Nishime EO, Cole CR, Blackstone EH, et al Heart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. JAMA 2000;284:1392–1398. - PubMed
    1. Shetler K, Marcus R, Froelicher VF, et al Heart rate recovery: Validation and methodologic issues. J Am Coll Cardiol 2001;38:1980–1987. - PubMed
    1. Morshedi‐Meidobi A, Larson MG, Levy D, et al Heart rate recovery after treadmill exercise testing and risk of cardiovascular disease events (The Framingham Heart Study). Am J Cardiol 2002;90:848–852. - PubMed
    1. Vivekananthan DP, Blackstone EH, Pothier CE, et al Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. J Am Coll Cardiol 2003;42:831–838. - PubMed