Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Dec;12(6):393-8.
doi: 10.1007/s11916-008-0067-5.

Pragmatic consideration of recent randomized, placebo-controlled clinical trials for treatment of fibromyalgia

Andrew J Holman  1
Affiliations
Review

Pragmatic consideration of recent randomized, placebo-controlled clinical trials for treatment of fibromyalgia

Andrew J Holman. Curr Pain Headache Rep. 2008 Dec.

Abstract

A flurry of recent randomized, placebo-controlled trials assessing dissimilar pharmacotherapeutic treatment options for fibromyalgia (FM) have been presented in the past few years. This review evaluates these trials in light of recent pathophysiological concepts germane to FM, including mood disorders, autonomic dysregulation, altered sleep stage architecture, and the diagnostic tender point controversy. Studies with gabapentin, pregabalin, duloxetine, milnacipran, sodium oxybate, and pramipexole for treatment of FM are discussed.

PubMed Disclaimer

References

    1. Pain. 2008 Jun;136(3):432-44 - PubMed
    1. J Rheumatol. 2000 Nov;27(11):2660-5 - PubMed
    1. Ann Rheum Dis. 2008 Apr;67(4):536-41 - PubMed
    1. Curr Opin Investig Drugs. 2006 Jan;7(1):33-9 - PubMed
    1. Rheumatol Int. 2007 Sep;27(11):999-1004 - PubMed

MeSH terms

Substances

LinkOut - more resources