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. 2009 Feb;107(2-3):249-54.
doi: 10.1016/j.schres.2008.09.030. Epub 2008 Oct 30.

The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample

Vladimir I Vladimirov  1 , Brion S Maher, Brandon Wormley, F Anthony O'Neill, Dermot Walsh, Kenneth S Kendler, Brien P Riley
Affiliations

The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample

Vladimir I Vladimirov et al. Schizophr Res. 2009 Feb.

Abstract

To replicate previous association between TAAR6 and schizophrenia, including our own finding in the Irish Study of High Density Schizophrenia Families (ISHDSF) sample, we genotyped 12 single nucleotide polymorphisms (SNPs) in the Irish Case-Control Study of Schizophrenia (ICCSS) sample. Only rs9389020 provided nominal evidence for association (p<0.0228), which did not withstand the permutation testing (p<0.2196). The combined odds ratio from ISHDSF and ICCSS samples [OR (95%CI)=1.0564 (1.0078-1.1074); p=0.02], while nominally significant, did not survive correction for multiple testing. Here we demonstrate that TAAR6 is not associated with schizophrenia in the ICCSS sample.

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Figures

Figure 1
Figure 1
1A represents the LD map of TAAR6 region in the HAPMAP data set and 1B the LD map of TAAR6 region in the ICCSS sample. The coloring is based on the D’ confidence interval method using Haploview default settings and reflects the LD strength; the values represent r2.
See this image and copyright information in PMC

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References

    1. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661–678. - PMC - PubMed
    1. Amann D, Avidan N, Kanyas K, Kohn Y, Hamdan A, Ben-Asher E, Macciardi F, Beckmann JS, Lancet D, Lerer B. The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23. Mol Psychiatry. 2006a;11:119–121. - PubMed
    1. Duan JB, Martinez M, Sanders AR, Hou CP, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV. Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. American Journal of Human Genetics. 2004a;75:624–638. - PMC - PubMed
    1. Duan S, Du J, Xu Y, Xing Q, Wang H, Wu S, Chen Q, Li X, Li X, Shen J, Feng G, He L. Failure to find association between TRAR4 and schizophrenia in the Chinese Han population. J Neural Transm. 2006a;113:381–385. - PubMed
    1. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol. 2003;25:115–121. - PubMed

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