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Comment
. 2008 Nov 4;105(44):16825-6.
doi: 10.1073/pnas.0809224105. Epub 2008 Oct 30.

Protein denaturation by urea: slash and bond

Peter J Rossky  1
Affiliations
Comment

Protein denaturation by urea: slash and bond

Peter J Rossky. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Electrostatic potentials mapped onto the surface of a simplified secondary structure cylinder representation (Left) and onto the solvent-accessible surface area of each helix (Right; cylindrical helices yellow) in the core formed by the A, G, and H helices in apomyoglobin (17). Electrostatic potentials from red to blue correspond to the range −5 kT/e to +5 kT/e, where k is Boltzmann's constant, e is the magnitude of the electron charge, and T is taken as 298 K. (Figure courtesy of Dr. Carlos F. Lopez, Department of Systems Biology, Harvard Medical School, Boston.)
See this image and copyright information in PMC

Comment on

References

    1. Zhang J, et al. NMR-study of the cold, heat, and pressure unfolding of ribonuclease A. Biochemistry. 1995;34:8631–8641. - PubMed
    1. Torrent J, et al. Distinct unfolding and refolding pathways of ribonuclease A revealed by heating and cooling temperature jumps. Biophys J. 2008;94:4056–4065. - PMC - PubMed
    1. Bennion BJ, Daggett V. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci USA. 2003;100:5142–5147. - PMC - PubMed
    1. Hua L, Zhou R, Thirumalai D, Berne BJ. Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding. Proc Natl Acad Sci USA. 2008;105:16928–16933. - PMC - PubMed
    1. Frank H, Franks F. Structural approach to the solvent power of water for hydrocarbons; urea as a structure breaker. J Chem Phys. 1968;48:4746–4757.

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