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. 2008 Aug;35(4-5):401-3.
doi: 10.1111/j.1744-313X.2008.00798.x.

Association of IL-6 gene polymorphism with the outcome of allogeneic haematopoietic stem cell transplantation in Czech patients

Z Ambruzova  1 , F Mrazek, L Raida, E Faber, J Onderkova, E Kriegova, K Indrak, M Petrek
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Association of IL-6 gene polymorphism with the outcome of allogeneic haematopoietic stem cell transplantation in Czech patients

Z Ambruzova et al. Int J Immunogenet. 2008 Aug.

Abstract

Interleukin-6 (IL-6) is an important pro-inflammatory mediator implicated in immune-mediated complications of allogeneic haematopoietic stem cell transplantation (aHSCT). In accord with previous reports, this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development of acute graft-versus-host disease and decreased survival after aHSCT.

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