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Review
. 2008 Oct 31:6:31.
doi: 10.1186/1741-7015-6-31.

25 years of HIV-1 research - progress and perspectives

Affiliations
Review

25 years of HIV-1 research - progress and perspectives

Mark A Wainberg et al. BMC Med. .

Abstract

Twenty-five years after the discovery and isolation of the human immunodeficiency virus by French and American scientists, much progress has been made in basic research, clinical treatment, and public health prevention measures for acquired immunodeficiency syndrome. Here, we summarize, in brief, advances that have been achieved and provide some perspectives on future challenges.

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Figures

Figure 1
Figure 1
A schematic illustration of the life-cycle of HIV-1 during the infection of a human cell. Entry, reverse transcription, nuclear entry, integration, transcription, translation, virus assembly and egress are shown.

References

    1. Gottlieb MS, Schroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA, Saxon A. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med. 1981;305:1425–1431. - PubMed
    1. Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vezinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) Science. 1983;220:868–871. doi: 10.1126/science.6189183. - DOI - PubMed
    1. Popovic M, Sarngadharan MG, Read E, Gallo RC. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science. 1984;224:497–500. doi: 10.1126/science.6200935. - DOI - PubMed
    1. Gallo RC. A reflection on HIV/AIDS research after 25 years. Retrovirology. 2006;3:72. doi: 10.1186/1742-4690-3-72. - DOI - PMC - PubMed
    1. UNAIDS http://www.unaids.org/en/knowledgecentre/hivdata/epidemiology/epislides.asp