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. 2008 Nov;14(11):1793-6.
doi: 10.3201/eid1411.080386.

Novel human rhinoviruses and exacerbation of asthma in children

Nino Khetsuriani  1 , Xiaoyan Lu, W Gerald Teague, Neely Kazerouni, Larry J Anderson, Dean D Erdman
Affiliations

Novel human rhinoviruses and exacerbation of asthma in children

Nino Khetsuriani et al. Emerg Infect Dis. 2008 Nov.

Abstract

To determine links between human rhinoviruses (HRV) and asthma, we used data from a case-control study, March 2003-February 2004, among children with asthma. Molecular characterization identified several likely new HRVs and showed that association with asthma exacerbations was largely driven by HRV-A and a phylogenetically distinct clade of 8 strains, genogroup C.

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Figures

Figure
Figure
Phylogenetic tree of partial virus capsid protein 1 (VP1) amino acid sequences of human rhinoviruses (HRVs) identified in 29 HRV-positive pediatric asthma patients, March 2003–February 2004, Atlanta, Georgia, USA (designated *), previously published sequences of strains QPM (GenBank accession no. EF186077), C024-C026 (accession nos. EF582385–EF582387), and NAT001 and NAT045 (accession nos. EF077279–EF077280). HRV prototype strains designated 1A, 1B, 2-100. Human enterovirus (HEV) 68/HRV87 (designated 68/87) is included as outgroup. Tree construction and bootstrap values determined with PAUP* (11).
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