Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Nov 4;14(5):345-7.
doi: 10.1016/j.ccr.2008.10.008.

Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia

Bernd B Zeisig  1 , Ngai Cheung, Jenny Yeung, Chi Wai Eric So
Affiliations
Free article
Comment

Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia

Bernd B Zeisig et al. Cancer Cell. .
Free article

Abstract

The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.

PubMed Disclaimer

Comment on

MeSH terms

Substances

LinkOut - more resources