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. 2008 Nov 4;14(5):349-51.
doi: 10.1016/j.ccr.2008.10.009.

Regulating the conversion between rounded and elongated modes of cancer cell movement

Daniel R Croft  1 , Michael F Olson
Affiliations
Free article

Regulating the conversion between rounded and elongated modes of cancer cell movement

Daniel R Croft et al. Cancer Cell. .
Free article

Abstract

Switching between elongated and rounded modes of movement allows invasive tumor cells to adapt to varying microenvironments. In a recent issue of Cell, Sanz-Moreno et al. identify DOCK3, NEDD9, WAVE2, and ARHGAP22 as key molecules regulating Rac and Rho signaling that determine the mode of movement driving melanoma cell metastasis.

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