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. 2009 Feb 11;197(2):462-5.
doi: 10.1016/j.bbr.2008.09.041. Epub 2008 Oct 14.

Exaggerated responses to stress in the BTBR T+tf/J mouse: an unusual behavioral phenotype

Robert Benno  1 , Yelena Smirnova, Susy Vera, Amanda Liggett, Norman Schanz
Affiliations

Exaggerated responses to stress in the BTBR T+tf/J mouse: an unusual behavioral phenotype

Robert Benno et al. Behav Brain Res. .

Abstract

This study shows that the BTBR T+tf/J mouse, a model for autism spectrum disorder (ASD), has increased levels of the stress hormone corticosterone, when compared to C57BL/6J mice. In addition, we have shown that tail suspension of the BTBR produces a heightened anxiety response in the elevated plus maze. These results suggest that the BTBR mouse is stressor-reactive exhibiting hormone responses that might predispose it to ASD.

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