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Comparative Study
. 2008 Nov;193(5):422-3.
doi: 10.1192/bjp.bp.107.041467.

Longitudinal MRI study in schizophrenia patients and their healthy siblings

Rachel G H Brans  1 , Neeltje E M van Haren, G Caroline M van Baal, Wouter G Staal, Hugo G Schnack, René S Kahn, Hilleke E Hulshoff Pol
Affiliations
Comparative Study

Longitudinal MRI study in schizophrenia patients and their healthy siblings

Rachel G H Brans et al. Br J Psychiatry. 2008 Nov.

Abstract

To investigate whether genetic and/or disease-related factors are involved in progressive structural brain changes in schizophrenia, magnetic resonance imaging scans with a 5-year scan interval were acquired in patients, their same-gender siblings and matched healthy controls. Structural equation modelling was applied to assess disease and familial effects. Whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process.

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