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Review
. 2008 Oct:42 Suppl 2:S101-5.
doi: 10.1038/bmt.2008.294.

Innovative approaches to treat steroid-resistant or steroid refractory GVHD

M Berger  1 , E Biasin, F Saglio, F Fagioli
Affiliations
Review

Innovative approaches to treat steroid-resistant or steroid refractory GVHD

M Berger et al. Bone Marrow Transplant. 2008 Oct.

Abstract

First-line treatment of GVHD is based on steroids and produces sustained responses in 50-80% of patients with acute GVHD (aGVHD) and 40-50% of patients with chronic GVHD (cGVHD) depending on the initial disease severity. Non-responding children are offered second-line therapy with combinations of various agents, but currently available agents have not improved survival in these high-risk populations. In this minireview, we will focus on new agents to treat GVHD in paediatric patients.

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