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. 2008 Dec;40(12):1404-6.
doi: 10.1038/ng.254. Epub 2008 Nov 2.

Lung cancer susceptibility locus at 5p15.33

James D McKay  1 , Rayjean J Hung, Valerie Gaborieau, Paolo Boffetta, Amelie Chabrier, Graham Byrnes, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, John McLaughlin, Frances Shepherd, Alexandre Montpetit, Steven Narod, Hans E Krokan, Frank Skorpen, Maiken Bratt Elvestad, Lars Vatten, Inger Njølstad, Tomas Axelsson, Chu Chen, Gary Goodman, Matt Barnett, Melissa M Loomis, Jan Lubiñski, Joanna Matyjasik, Marcin Lener, Dorota Oszutowska, John Field, Triantafillos Liloglou, George Xinarianos, Adrian Cassidy; EPIC Study; Paolo Vineis, Francoise Clavel-Chapelon, Domenico Palli, Rosario Tumino, Vittorio Krogh, Salvatore Panico, Carlos A González, José Ramón Quirós, Carmen Martínez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Kay Tee Kham, Timothy Key, H Bas Bueno-de-Mesquita, Petra Hm Peeters, Antonia Trichopoulou, Jakob Linseisen, Heiner Boeing, Göran Hallmans, Kim Overvad, Anne Tjønneland, Merethe Kumle, Elio Riboli, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Fumihiko Matsuda, Helene Blanche, Ivo Gut, Simon Heath, Mark Lathrop, Paul Brennan
Affiliations

Lung cancer susceptibility locus at 5p15.33

James D McKay et al. Nat Genet. 2008 Dec.

Abstract

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P = 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

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Figures

Figure 1
Figure 1
Forest plot representing lung cancer risk and the two variants in the 5p region (rs402710 and rs2736100). Apart from the odds ratios for heterozygous and homozygous effect (*), odds ratios and 95% confidence intervals are derived from the per-allele model. All models are adjusted for age, sex and country. The overall OR is shown by the broken vertical line. P values are from heterogeneity tests.
See this image and copyright information in PMC

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