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. 2009 Mar;25(3):251-7.
doi: 10.1007/s10554-008-9377-2. Epub 2008 Nov 1.

In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis

Stephen G Worthley  1 , Zhuang Y Zhang, Josef Machac, Gérard Helft, Cheuk Tang, Gary Y H Liew, Azfar G Zaman, Matthew I Worthley, Zahi A Fayad, Monte S Buchsbaum, Valentin Fuster, Juan J Badimon
Affiliations

In vivo non-invasive serial monitoring of FDG-PET progression and regression in a rabbit model of atherosclerosis

Stephen G Worthley et al. Int J Cardiovasc Imaging. 2009 Mar.

Abstract

We investigated the ability of fluorodeoxyglucose positron emission tomography (FDG PET) imaging to serially monitor macrophage content in a rabbit model of atherosclerosis. Atherosclerosis was induced in rabbits (n = 8) by a combination of atherogenic diet and balloon denudation of the aorta. At the end of nine months, the rabbits were randomized to a further six months of the same atherogenic diet (progression group) or normal diet (regression group). In vivo uptake of FDG by the thoracic aorta was measured using aortic uptake-to-blood radioactivity ratios at the start and end of the randomized period. A significant increase in FDG uptake of the progression group after continued cholesterol feeding (aortic uptake-to-blood radioactivity: 0.57 +/- 0.02 to 0.68 +/- 0.02, P = 0.001), and a corresponding fall in FDG uptake of the regression group after returning to a normal chow diet (aortic uptake-to-blood radioactivity ratios: 0.67 +/- 0.02 to 0.53 +/- 0.02, P < 0.0001). FDG PET can quantify in vivo macrophage content and serially monitor changes in FDG activity in this rabbit model.

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Comment in

  • Monitoring plaque composition: is it worthwile?
    van der Laarse A, van der Wall EE. van der Laarse A, et al. Int J Cardiovasc Imaging. 2009 Mar;25(3):259-61. doi: 10.1007/s10554-008-9390-5. Epub 2008 Nov 27. Int J Cardiovasc Imaging. 2009. PMID: 19037748 No abstract available.

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