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. 1991 Apr;286(1):264-9.
doi: 10.1016/0003-9861(91)90039-l.

Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity

D Boscoboinik  1 , A Szewczyk, A Azzi
Affiliations

Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity

D Boscoboinik et al. Arch Biochem Biophys. 1991 Apr.

Abstract

Alpha-Tocopherol (vitamin E) protects against free radical damage, which has been implicated in aging, cancer initiation, and atherosclerosis. We have found that physiological concentrations of alpha-tocopherol specifically inhibited aorta smooth muscle cell (VSMC, line A7r5) proliferation and protein kinase C (PKC) activity. Other water and lipid soluble antioxidants were inactive. alpha-Tocopherol inhibition of PKC and of VSMC proliferation may represent a physiological mechanism, relevant to the onset of diseased states such as atherosclerosis.

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