doi: 10.1016/0003-9861(91)90039-l.
Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity
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- PMID: 1897954
- DOI: 10.1016/0003-9861(91)90039-l
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Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity
Arch Biochem Biophys.
1991 Apr.
Abstract
Alpha-Tocopherol (vitamin E) protects against free radical damage, which has been implicated in aging, cancer initiation, and atherosclerosis. We have found that physiological concentrations of alpha-tocopherol specifically inhibited aorta smooth muscle cell (VSMC, line A7r5) proliferation and protein kinase C (PKC) activity. Other water and lipid soluble antioxidants were inactive. alpha-Tocopherol inhibition of PKC and of VSMC proliferation may represent a physiological mechanism, relevant to the onset of diseased states such as atherosclerosis.
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