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. 2008 Nov 26;130(47):15808-10.
doi: 10.1021/ja8039585.

Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier

Wei Wei  1 , Guang-Hui Ma, Gang Hu, Di Yu, Tom McLeish, Zhi-Guo Su, Zhe-Yu Shen
Affiliations

Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier

Wei Wei et al. J Am Chem Soc. .

Abstract

One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.

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