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Comment
. 2008 Nov 1;22(21):2908-13.
doi: 10.1101/gad.1740808.

New cell or new cycle?

Olivier Ganier  1 , Marcel Mechali
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Free article
Comment

New cell or new cycle?

Olivier Ganier et al. Genes Dev. .
Free article

Abstract

In mammals, trophoblast giant (TG) cell differentiation is characterized by a physiological endoreduplication, resulting in genome size augmentation. A recent study by Ullah and colleagues (pp. 3024-3036), published in this issue of Genes & Development, now elucidates the role of the cyclin-dependent kinase inhibitors (CKIs), p21 and p57, in mammalian endocycle regulation.

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