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. 2009 Jan;42(1-2):108-10.
doi: 10.1016/j.clinbiochem.2008.10.002. Epub 2008 Oct 22.

Cystatin C for early detection of renal impairment in diabetes

D Willems  1 , F Wolff, F Mekahli, C Gillet
Affiliations

Cystatin C for early detection of renal impairment in diabetes

D Willems et al. Clin Biochem. 2009 Jan.

Erratum in

Abstract

Objectives: Evaluation of glomerular filtration rate is of crucial importance in diabetes. Cystatin C, a cysteine protease inhibitor seems to be an interesting parameter.

Design and methods: 67 diabetic patients with normal creatinine are evaluated. Cystatin C is compared to renal markers, by reference to Cr EDTA clearance.

Results: Significant correlations are found between cystatin C and creatinine (r=0.54). GFR MDRD (r=-0.47) and GFR Cr EDTA (r=-0.47). The AUC of the receiver operating curves is better for GFR MDRD (0.83) and cystatin C (0.75) than for creatinine (0.63) considering the cut off value of 80 mL/min for GFR EDTA.

Conclusion: Cystatin C seems to be a more sensitive parameter than creatinine for the detection of an incipient nephropathy in diabetes.

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