Develop-WNTs in somatic cell reprogramming
- PMID: 18983957
- DOI: 10.1016/j.stem.2008.10.011
Develop-WNTs in somatic cell reprogramming
Abstract
Two manuscripts published recently in Cell Stem Cell (Lluis et al., 2008 [this issue]; Marson et al., 2008) show that Wnt-beta-catenin signaling stimulates nuclear reprogramming. These two studies, using distinct reprogramming methods, offer insights into the mechanisms underlying acquisition and maintenance of pluripotency.
Comment on
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Wnt signaling promotes reprogramming of somatic cells to pluripotency.Cell Stem Cell. 2008 Aug 7;3(2):132-5. doi: 10.1016/j.stem.2008.06.019. Cell Stem Cell. 2008. PMID: 18682236 Free PMC article. No abstract available.
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Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion.Cell Stem Cell. 2008 Nov 6;3(5):493-507. doi: 10.1016/j.stem.2008.08.017. Cell Stem Cell. 2008. PMID: 18983965
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