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. 2008 Oct 31;135(3):401-6.
doi: 10.1016/j.cell.2008.10.017.

The autistic neuron: troubled translation?

Raymond J Kelleher 3rd  1 , Mark F Bear
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Free article

The autistic neuron: troubled translation?

Raymond J Kelleher 3rd et al. Cell. .
Free article

Abstract

Autism is a complex genetic disorder, but single-gene disorders with a high prevalence of autism offer insight into its pathogenesis. Recent evidence suggests that some molecular defects in autism may interfere with the mechanisms of synaptic protein synthesis. We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognitive impairment and savant abilities.

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