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Comment
. 2008 Oct 31;135(3):408-10.
doi: 10.1016/j.cell.2008.10.009.

It takes a (dysfunctional) village to raise a tumor

Karlyne M Reilly  1 , Terry Van Dyke
Affiliations
Comment

It takes a (dysfunctional) village to raise a tumor

Karlyne M Reilly et al. Cell. .

Abstract

The tumor microenvironment is known to play an important role in tumorigenesis. In this issue, Yang et al. (2008) demonstrate that mast cells heterozygous for the Nf1 gene promote the growth of neurofibromas in a mouse model of neurofibromatosis and that genetic and pharmacological inhibition of these cells is sufficient to block tumor growth.

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