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Randomized Controlled Trial
. 2009 Mar;36(3):475-83.
doi: 10.1007/s00259-008-0969-9. Epub 2008 Nov 5.

The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects

Sargo Aalto  1 , Jussi Hirvonen, Valtteri Kaasinen, Nora Hagelberg, Jaana Kajander, Kjell Någren, Timo Seppälä, Juha O Rinne, Harry Scheinin, Jarmo Hietala
Affiliations
Randomized Controlled Trial

The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects

Sargo Aalto et al. Eur J Nucl Med Mol Imaging. 2009 Mar.

Abstract

Purpose: The dopamine D(2)/D(3) receptor ligand [(11)C]FLB 457 and PET enable quantification of low-density extrastriatal D(2)/D(3) receptors, but it is uncertain whether [(11)C]FLB 457 can be used for measuring extrastriatal dopamine release.

Methods: We studied the effects of d-amphetamine (0.3 mg/kg i.v.) on extrastriatal [(11)C]FLB 457 binding potential (BP(ND)) in a randomized, double-blind, placebo-controlled study including 24 healthy volunteers.

Results: The effects of d-amphetamine on [(11)C]FLB 457 BP(ND) and distribution volume (V(T)) in the frontal cortex were not different from those of placebo. Small decreases in [(11)C]FLB 457 BP(ND) were observed only in the posterior cingulate and hippocampus. The regional changes in [(11)C]FLB 457 BP(ND) did not correlate with d-amphetamine-induced changes in subjective ratings of euphoria.

Conclusion: This placebo-controlled study showed that d-amphetamine does not induce marked changes in measures of extrastriatal dopamine D(2)/D(3) receptor binding. Our results indicate that [(11)C]FLB 457 PET is not a useful method for measuring extrastriatal dopamine release in humans.

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References

    1. J Neurosci. 2005 Mar 9;25(10):2471-7 - PubMed
    1. J Cereb Blood Flow Metab. 2007 Mar;27(3):606-17 - PubMed
    1. Synapse. 2008 Jun;62(6):399-408 - PubMed
    1. J Neurosci. 1998 Jul 15;18(14):5545-54 - PubMed
    1. J Cereb Blood Flow Metab. 2007 Feb;27(2):369-77 - PubMed

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