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Review
. 2008 Oct 28;14(40):6261-4.
doi: 10.3748/wjg.14.6261.

Solitary fibrous tumor of the liver expressing CD34 and vimentin: a case report

Dimitris-P Korkolis  1 , Katerina Apostolaki, Chrysanthi Aggeli, George Plataniotis, Emmanuel Gontikakis, Dimitra Volanaki, Maria Sebastiadou, Dimitris Dimitroulopoulos, Dimitris Xinopoulos, George-N Zografos, Perikles-P Vassilopoulos
Affiliations
Review

Solitary fibrous tumor of the liver expressing CD34 and vimentin: a case report

Dimitris-P Korkolis et al. World J Gastroenterol. .

Abstract

A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported. An 82-year-old female presented with left upper abdominal discomfort, a firm mass on palpation, and imaging studies revealed a large tumor, 15 cm in diameter, arising from the left lobe of the liver. A formal left hepatectomy was performed. Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma. Immunohistochemistry disclosed diffuse CD34 and positive vimentin, supporting the diagnosis of a benign SFT. The patient remained well 21 months after surgery. SFT of the liver is a very rare neoplasm of mesenchymal origin. In most cases it is a benign lesion, although some may have malignant histological features and recur locally or metastasize. With less than 30 reported cases in the literature, little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy. Complete surgical resection remains the cornerstone of its treatment.

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Figures

Figure 1
Figure 1
Magnetic resonance imaging demonstrating a large, 15 cm in size, well-circumscribed lesion in the left hepatic lobe, compressing the stomach, pancreas and hepatoduodenal ligament.
Figure 2
Figure 2
Gross appearance of a firm, well-demarcated and lobulated SFT of the liver (A) and greyish-white SFT of the liver with whorled and fasciculated surface and focal myxoid degeneration on cut section (B).
Figure 3
Figure 3
Tumor cells. A: Microscopy showing a tumor composed of uniform collagen-forming spindle cells arranged in interlacing fascicles and well-encapsulated and differentiated from the adjacent non-cirrhotic liver parenchyma (HE, × 100); B: CD34 immunohistochemical staining demonstrating diffusely strong reactivity (× 200); C: Tumor cells showing diffuse immunohistochemical positivity for vimentin (× 200).
See this image and copyright information in PMC

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