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Guideline
. 2009 Jan;83(2):494-7.
doi: 10.1128/JVI.01976-08. Epub 2008 Nov 5.

Guidelines for naming nonprimate APOBEC3 genes and proteins

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Guideline

Guidelines for naming nonprimate APOBEC3 genes and proteins

Rebecca S LaRue et al. J Virol. 2009 Jan.
No abstract available

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Figures

FIG. 1.
FIG. 1.
(A) Schematics of the A3 repertoires of mammals whose genomes have been sequenced. Z1, Z2, and Z3 domains are shown in green, orange and blue, respectively. For all of the indicated species (and likely all mammals), CBX6 is located immediately upstream and CBX7 downstream of the A3 locus. Either macaque A3A does not exist, or its genomic sequence is not quite complete. The inferred ancestral A3 repertoire was deduced through comparative studies (13). The numbers at the phylogenetic tree branch points indicate the approximate time, in millions of years, since the divergence of the ancestors of the clades of the indicated present-day species (1). (B) Highlights of amino acid conservation among the three distinct Z-domain groups and within each individual group (based on multiple sequence alignments) (13). Residues discussed in the text are in color or boldface, and other notable residues are in gray. An “x” specifies nearly any amino acid.

References

    1. Bininda-Emonds, O. R., M. Cardillo, K. E. Jones, R. D. MacPhee, R. M. Beck, R. Grenyer, S. A. Price, R. A. Vos, J. L. Gittleman, and A. Purvis. 2007. The delayed rise of present-day mammals. Nature 446507-512. - PubMed
    1. Bogerd, H. P., R. L. Tallmadge, L. J. Oaks, S. Carpenter, and B. R. Cullen. 2008. Equine infectious anemia virus resists the antiretroviral activity of equine APOBEC3 proteins through a packaging-independent mechanism. J. Virol. 8211889-11901. - PMC - PubMed
    1. Chen, K. M., E. Harjes, P. J. Gross, A. Fahmy, Y. Lu, K. Shindo, R. S. Harris, and H. Matsuo. 2008. Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G. Nature 452116-119. - PubMed
    1. Chimpanzee Sequencing and Analysis Consortium. 2005. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 43769-87. - PubMed
    1. Chiu, Y. L., and W. C. Greene. 2008. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. Annu. Rev. Immunol. 26317-353. - PubMed

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