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. 1991 Jan;11(1):182-91.
doi: 10.1128/mcb.11.1.182-191.1991.

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons

D J Lew  1 , T Decker, I Strehlow, J E Darnell
Affiliations

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons

D J Lew et al. Mol Cell Biol. 1991 Jan.

Abstract

The gene encoding a 67-kDa cytoplasmic guanylate-binding protein (GBP) is transcriptionally induced in cells exposed to interferon of either type I (alpha interferon [IFN-alpha] or type II (IFN-gamma). The promoter of the GBP gene was cloned and found to contain an IFN-alpha-stimulated response element, which mediated the response of the GBP gene to IFN-alpha. On the basis of transfection experiments with recombinant plasmids, two different elements were delineated. Both were required to obtain the maximal response of the GBP gene to IFN-gamma: the IFN-alpha-stimulated response element and an overlapping element termed the IFN-gamma activation site. Different proteins that act on each element were investigated, and their possible involvement in IFN-gamma-induced transcriptional regulation is discussed.

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