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Review
. 2009 Jan;124(6):561-77.
doi: 10.1007/s00439-008-0583-8. Epub 2008 Nov 6.

Advances in osteoclast biology resulting from the study of osteopetrotic mutations

T Segovia-Silvestre  1 , A V Neutzsky-Wulff, M G Sorensen, C Christiansen, J Bollerslev, M A Karsdal, K Henriksen
Affiliations
Review

Advances in osteoclast biology resulting from the study of osteopetrotic mutations

T Segovia-Silvestre et al. Hum Genet. 2009 Jan.

Abstract

Osteopetrosis is the result of mutations affecting osteoclast function. Careful analyses of osteopetrosis have provided instrumental information on bone remodeling, including the coupling of bone formation to bone resorption. Based on a range of novel genetic mutations and the resulting osteoclast phenotypes, we discuss how osteopetrosis models have clarified the function of the coupling of bone formation to bone resorption, and the pivotal role of the osteoclast and their function in this phenomenon. We highlight the distinct possibility that osteoclast activities can be divided into two separate avenues: bone resorption and control of bone formation.

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