WASp stings mature lymphocytes
- PMID: 18988873
- PMCID: PMC2581988
- DOI: 10.1182/blood-2008-09-176685
WASp stings mature lymphocytes
Abstract
WAS is an X-linked immunodeficiency disease caused by mutations in WASp. Meyer-Bahlburg and colleagues and Westerberg and colleagues in this issue of Blood have investigated lymphocyte subpopulations in WASp+/- mice and found that WASp confers a selective advantage to the most mature T and B cells.
Conflict of interest statement
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Comment on
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Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.Blood. 2008 Nov 15;112(10):4158-69. doi: 10.1182/blood-2008-02-140814. Epub 2008 Aug 7. Blood. 2008. PMID: 18687984 Free PMC article.
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WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.Blood. 2008 Nov 15;112(10):4139-47. doi: 10.1182/blood-2008-02-140715. Epub 2008 Sep 4. Blood. 2008. PMID: 18772454 Free PMC article.
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- Westerberg L, Larsson M, Hardy SJ, et al. Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration and homing and a delayed humoral immune response. Blood. 2005;105:1144–1152. - PubMed
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