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Case Reports
. 2008 Autumn;38(4):393-400.

Case report: Paenibacillus thiaminolyticus: a new cause of human infection, inducing bacteremia in a patient on hemodialysis

Jie Ouyang  1 , Zhiheng Pei, Larry Lutwick, Sharvari Dalal, Liying Yang, Nicholas Cassai, Kuldip Sandhu, Bruce Hanna, Rosemary L Wieczorek, Martin Bluth, Matthew R Pincus
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Case Reports

Case report: Paenibacillus thiaminolyticus: a new cause of human infection, inducing bacteremia in a patient on hemodialysis

Jie Ouyang et al. Ann Clin Lab Sci. 2008 Autumn.

Abstract

Paenibacilli are gram-positive, aerobic bacteria that are related to Bacilli but differ in the DNA encoding their 16S rRNA. Until recently, these organisms were not known to cause human disease. There are now several reports of human infection caused by a few members of this genus, most commonly by P. alvei. We report a human infection in a patient with a permacath for chronic hemodialysis who was found to have bacteremia caused by P. thiaminolyticus, which is an environmental bacterium that has never been found to cause human disease. We identified this bacterium by biochemical tests, cloning, sequencing the genomic DNA encoding its 16S rRNA, growth characteristics, and electron microscopic studies. This constitutes the first report of a human infection caused by this organism.

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Figures

Fig. 1
Fig. 1
Identification of BKBLC2156 by 16S rRNA gene-based phylogenetic analysis. Bootstrap values (based on 500 replicates) are represented at each node when >50%, and the branch length index is represented below the phylogram. Included in the analyses are clones of 16S rRNA genes from BKBLC 2156 as well as 16S rRNA gene sequences of P. thiaminolyticus (DSM 7262) and P. popilliae (ATCC 14706) type strains. Their Genbank accession numbers are shown after the species name.
See this image and copyright information in PMC

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