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. 2008 Dec 15;18(24):6468-70.
doi: 10.1016/j.bmcl.2008.10.061. Epub 2008 Oct 17.

Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists

Mingde Xia  1 , Cuifen Hou, Duane DeMong, Scott Pollack, Meng Pan, Monica Singer, Michele Matheis, William Murray, Druie Cavender, Michael Wachter
Affiliations

Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists

Mingde Xia et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and structure-activity relationship of a series of 7-azaindole piperidine derivatives are described. SAR studies led to the discovery of the potent CCR2 antagonists displaying IC(50) values in the nanomolar range. The representative compound 15 showed reasonable P450 and pharmacokinetics profile.

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