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Meta-Analysis
. 2010 Jul;36(4):723-31.
doi: 10.1093/schbul/sbn146. Epub 2008 Nov 5.

Dyskinesia and parkinsonism in antipsychotic-naive patients with schizophrenia, first-degree relatives and healthy controls: a meta-analysis

Jeroen P F Koning  1 , Diederik E Tenback, Jim van Os, André Aleman, René S Kahn, Peter N van Harten
Affiliations
Meta-Analysis

Dyskinesia and parkinsonism in antipsychotic-naive patients with schizophrenia, first-degree relatives and healthy controls: a meta-analysis

Jeroen P F Koning et al. Schizophr Bull. 2010 Jul.

Abstract

Background: Several studies have reported the presence of dyskinesia and parkinsonism in antipsychotic-naive patients with schizophrenia as well as in their first-degree relatives. These movement disorders may therefore form an integral part of the illness and its (genetic) liability.

Method: A systematic search was conducted in the Medline, EMBASE, and PsychINFO databases to identify studies reporting on dyskinesia and parkinsonism assessed in antipsychotic-naive patients with schizophrenia (n = 213) and controls (n = 242) and separately in nonill first-degree relatives (n = 395) and controls (n = 379). Effect sizes were pooled using random-effect models to calculate odds ratios (ORs) to compare the risk of these movement disorders among patients and healthy relatives each with matched controls.

Results: Antipsychotic-naive schizophrenia was found to be strongly associated with dyskinesia (OR: 3.59, 95% confidence interval [CI]: 1.53-8.41) and parkinsonism (OR: 5.32, 95% CI: 1.75-16.23) compared with controls. Dyskinesia and parkinsonism were also significantly more prevalent in healthy first-degree relatives of patients with schizophrenia as compared with healthy controls (OR: 1.38, 95% CI: 1.06-1.81, and OR: 1.37, 95% CI: 1.05-1.79, respectively).

Conclusion: The results suggest that movement disorders, and by inference abnormalities in the nigrostriatal pathway, are not only associated with schizophrenia itself but may also be related to the (genetic) risk of developing the disease.

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Figures

Fig. 1.
Fig. 1.
Flowchart of Included Studies.
Fig. 2.
Fig. 2.
Forest Plot and Odds Ratios of Dyskinesia in Antipsychotic-Naive Patients With Schizophrenia Compared With Healthy Controls.
Fig. 3.
Fig. 3.
Forest Plot and Odds Ratios of Parkinsonism in Antipsychotic-Naive Patients With Schizophrenia Compared With Healthy Controls.
Fig. 4.
Fig. 4.
Forest Plot and Odds Ratios of Dyskinesia in Healthy First-Degree Relatives of Patients With Schizophrenia compared with Healthy Controls.
Fig. 5.
Fig. 5.
Forest Plot and Odds Ratios of Parkinsonism in Healthy First-Degree Relatives of Patients With Schizophrenia and in Healthy Controls.
See this image and copyright information in PMC

References

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