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. 2008 Dec 5;73(23):9458-60.
doi: 10.1021/jo802021t.

Synthesis of sugar nucleotides by application of phosphoramidites

Henrik Gold  1 , Pieter van Delft, Nico Meeuwenoord, Jeroen D C Codée, Dmitri V Filippov, Gerrit Eggink, Herman S Overkleeft, Gijs A van der Marel
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Synthesis of sugar nucleotides by application of phosphoramidites

Henrik Gold et al. J Org Chem. .

Abstract

A new method for the construction of pyrophosphates is reported based on the coupling of a sugar phosphate and a nucleoside phosphoramidite. The in situ formed phosphate-phosphite intermediate was subsequently oxidized with tBuOOH. Three UDP-N-acetylglucosamine derivatives were prepared using this one-pot procedure in good yields.

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