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Review
. 2008 Nov;3(3):162-77.
doi: 10.2174/157489208786242322.

Update on aurora kinase inhibitors in gynecologic malignancies

Xia Tao  1 , Hye S Chon, Siqing Fu, John J Kavanagh, Wei Hu
Affiliations
Review

Update on aurora kinase inhibitors in gynecologic malignancies

Xia Tao et al. Recent Pat Anticancer Drug Discov. 2008 Nov.

Abstract

Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis during mitosis and play a role in tumorigenesis and tumor progression in humans. Aurora kinase A and Aurora kinase B are overexpressed in some gynecologic cancers, and their overexpression is associated with poor prognosis. Thus, targeting of Aurora kinases has become an attractive strategy for pharmaceutical companies, who have developed more than 30 Aurora kinase inhibitors for treatment of cancers. Some of these inhibitors have been shown to be effective in targeted therapies for human cancer, and others are currently being investigated. In this review, we summarize the most recent advances in preclinical studies and clinical trials of patented Aurora kinase inhibitors for gynecologic tumors.

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Figures

Figure 1
Figure 1
Sensitizing Cancer Cells to SAC inhibition plus microtubule targeting agents to optimize enhanced Apoptosis.
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